“ What if potions and tonics had negative side effects? Potions of increased strength cause violent tempers, or damage joints. What if potions of dexterity caused tremors, or palsy?
What if they were addictive, and had withdrawal symptoms?
Could someone make a bad batch? No one use the brown strength potion!”
“ Temple of some malign being invites you warmly and offers help (curing,needed spell etc) for some minor sacrifice . Sacrifices must be everytime bigger to work - up to living inteligent creatures. Maybe you pay some other price,too...”
“ The hammer of a war-god avatar, this massive weapon must be wielded by a giant or other supernaturally strong being. When struck against the ground, a massive seismic wave will propagate outward from the wielder subjecting all in its wake to a massive earthquake. This quake is strong enough to shatter castle walls.”